Welcome to Prabodh’s Lab

LAB NEWS

  • Sweta Bhambani submitted her thesis.
  • *Congratulations Dr. Smita Kumar and Dr. Ashutosh Pandey for winning the most prestigious Young Scientist Medal-2017 from Indian National Science Academy (INSA).
  • Department of Biotechnology, New Delhi sanctioned Centre of Excellence and Innovation in Biotechnology (CEIB) on Secondary plant product pathway engineering
  • Dr. Smita awarded Indo-Australian Career Boosting Gold Fellowship from DBT to work in Prof. Anthony Miller's group
  • Tapsi Shukla and Aditya V. Agarwal submitted their thesis.
  • 7 publications received Best Research Paper Award-2016 from the Institute.
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    RESEARCH THEMES

    Pathway Engineering for secondary plant products

    In the area of secondary plant metabolites, main focus has been to study the expression and regulation of genes involved in biosynthesis of important molecules, which are beneficial for human health. Lab has attained success in different aspects such as:

  • Transgenic plants accumulate isoflavones. in flower petals, but leaf tissue was devoid of these phytoceuticals.
  • Transformation and development of transgenic plants.
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    Open Position

       There are currently no vacancies available.

     

     

     

     

     

     

     

     

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    Publications

    2013

    1. Kushwaha AK, Sangwan NS, Trivedi PK, Negi AS, Misra LN, Sangwan RS (2013) Tropine forming tropinone reductase gene from Withania somnifera (Ashwagandha): biochemical characteristics of the recombinant enzyme and novel physiological overtones of tissue-wide gene expression patterns. PLoS ONE 8:e74777
    2. Khedgikar V, Kushwaha  P, Gautam  J, Verma A,  Changkija B, Kumar A,  Sharma S, Nagar G, Singh D, Trivedi  PK, Sangwan NS, Mishra PK, Trivedi R (2013) Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone. Cell Death & Disease 4:e778. (Nature Publishing Group)
    3. Shukla D, Kesari R, Tiwari M, Dwivedi S, Tripathi RD, Nath P, Trivedi PK (2013) Expression of Ceratophyllum demersum phytochelatin synthase, CdPCS1, in Escherichia coli and Arabidopsis enhances heavy metal(loid)s accumulation. Protoplasma 250:1263-1272
    4. Pathak S, Lakhwani D, Gupta P, Mishra BK, Shukla S, Asif MH,  Trivedi PK (2013) Comparative transcriptome analysis using high papaverine mutant of Papaver somniferum reveals pathway and uncharacterized steps of papaverine biosynthesis. PLoS ONE 8(5): e65622
    5. Gupta P, Goel R, Pathak S, Srivastava A, Singh SP, Sangwan RS, Asif MH, Trivedi  PK (2013) De novo assembly, functional annotation and comparative analysis of Withania somnifera leaf and root transcriptomes to identify putative genes involved in the withanolides biosynthesis. PLoS ONE 8(5): e62714
    6. Shukla D, Tiwari M, Tripathi RD, Nath P, Trivedi PK (2013) Synthetic phytochelatins complement a phytochelatin-deficient Arabidopsis mutant and enhance the accumulation of heavy metal(loid)s. Biochemical and Biophysical Research Communications 434:664–669
    7. Kumar S, Asif MH, Chakrabarty D, Tripathi RD, Dubey RS, Trivedi PK (2013) Differential expression of rice Lambda class GST gene family members during plant growth, development, and in response to stress conditions. Plant Molecular Biology Reporter  31:569–580
    8. Kumar S, Asif MH, Chakrabarty D, Tripathi RD, Dubey RS, Trivedi PK (2013) Expression of a rice Lambda class of Glutathione S-transferase, OsGSTL2, in Arabidopsis provides tolerance to heavy metal and other abiotic stresses. Journal of Hazardous Materials 248-249C: 228-237
    9. Gupta P, Agarwal AV, Akhtar N, Sangwan RS, Singh SP, Trivedi PK (2013) Cloning and characterization of 2-C-methyl-D-erythritol-4-phosphate pathway genes for isoprenoid biosynthesis from Indian Ginseng, Withania somnifera. Protoplasma 250: 285-295
    10. Tripathi P, Tripathi RD, Singh RP, Dwivedi S, Goutama D, Shri M, Trivedi PK, Chakrabarty D (2013) Silicon mediated arsenic tolerance in rice (Oryza sativa L.) through lowering of arsenic uptake and improved antioxidant defence system. Ecological Engineering 52: 96–103
    11. Dave R, Singh PK, Tripathi P, Shri M, Dixit G, Dwivedi S, Chakrabarty D, Trivedi PK, Sharma YK, Dhankher OP, Corpas FJ, Barroso JB, Tripathi RD (2013) Arsenite Tolerance is Related to Proportional Thiolic Metabolite Synthesis in Rice (Oryza sativa L.). Arch Environ Contam Toxicol 64:235-242
    12. Tripathi P, Tripathi RD, Singh RP, Dwivedi S, Chakrabarty D, Trivedi PK, Adhikari B (2013) Arsenite tolerance in rice (Oryza sativa L.) involves coordinated role of metabolic pathways of thiols and amino acids. Environmental Science and Pollution Research 20: 884-896
    13. Akhtar N, Gupta P, Sangwan NS, Sangwan RS, Trivedi PK (2013) Cloning and functional characterization of 3-hydroxy-3-methylglutaryl-Coenzyme A reductase gene from Withania somnifera: an important medicinal plant. Protoplasma 250:613-622
    14. Shri M, Rai A, Verma PK, Misra P, Dubey S, Kumar S, Verma S, Gautam N, Tripathi RD, Trivedi PK, Chakrabarty D (2013) An improved Agrobacterium-mediated transformation of recalcitrant indica rice (Oryza sativa L.) cultivars. Protoplasma 250: 631-636
    15. Dave R, Mishra A, Tripathi RD, Dwivedi S, Tripathi P, Dixit G, Sharma YK, Trivedi PK, Corpus FJ, Barroso JB, Chakrabarty D (2013) Arsenate and arsenite exposure modulate antioxidants and amino acids  in contrasting arsenic accumulating rice (Oryza sativa L.) genotypes. Journal of Hazardous Materials 262:1123-1131

     

     

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